MOTS-c
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) peptide is a mitochondrial product synthesized from the 12S rRNA gene sequence. It has been the subject of research on metabolic homeostasis and insulin sensitivity, as well as AMPK activation.
About MOTS-c
MOTS-c is a peptide made up of 16 amino acids that is exclusively coded by the mitochondrial genome rather than the nuclear genome. Therefore, it forms one of the recent discoveries referred to as MDPs that have immense importance in metabolic studies.
Studies on MOTS-c have been conducted with respect to its significance in AMPK activation, regulation of folate cycle, and metabolic flexibility in skeletal muscles. It has also been examined in relation to insulin sensitivity and aging in metabolic decline.
Research Areas
- AMPK activation and metabolic homeostasis pathway research
- Insulin sensitivity and glucose regulation studies in animal models
- Mitochondrial function and biogenesis investigation in vitro
- Folate and methionine cycle regulation research
- Age-related metabolic decline and longevity research in laboratory settings
- Exercise mimetic and skeletal muscle metabolism studies
⚠ Research Use Only.
All products supplied by PeptidesX are intended strictly for in-vitro laboratory and scientific research. Not for human consumption, medical use, veterinary use, or therapeutic application. Researchers are responsible for compliance with all applicable regulations in their jurisdiction.
Identity & Purity
HPLC / MS-UPLC| Test | Specification | Result |
| Appearance | White lyophilised powder | ✓ Conforms |
| HPLC Purity | ≥ 98.0% | 99.0% ✓ |
| MS Molecular Weight | Expected ± 0.5 Da | Confirmed ✓ |
| Amino Acid Analysis | Theoretical sequence | Confirmed ✓ |
| Water Content (KF) | ≤ 8.0% | 5.4% ✓ |
| Net Peptide Content | ≥ 85.0% | 90.8% ✓ |
Safety Testing
Endotoxin / Metals| Test | Specification | Result |
| Endotoxin (LAL) | ≤ 5 EU/mg | 0.9 EU/mg ✓ |
| Bioburden | ≤ 100 CFU/g | <10 CFU/g ✓ |
| Lead (Pb) | ≤ 10 ppm | <0.1 ppm ✓ |
| Arsenic (As) | ≤ 5 ppm | <0.1 ppm ✓ |
| Mercury (Hg) | ≤ 3 ppm | <0.1 ppm ✓ |
| Cadmium (Cd) | ≤ 5 ppm | <0.1 ppm ✓ |
Solubility: Water / PBS. Mix gently by rolling — do not vortex.
Returns: Sealed, unopened vials may be returned within 14 days of receipt. Opened vials cannot be returned.
Purchase of MOTS-c peptides is fully legal in the United Kingdom for research purposes only. All products sold by our company are meant for in-vitro laboratory research use and are fully compliant with UK regulations. PeptidesX does not sell products meant for medical use.
Each order contains: a lyophilized peptide vial, batch-specific Certificate of Analysis (validated via HPLC and MS), a disclaimer and cold chain shipping.
Orders received before 3 PM Monday through Friday will be processed on the same day using Royal Mail Tracked 24 service. Tracking details are sent via e-mail. Most UK deliveries arrive on next business day.
Yes. PeptidesX offers volume discounts to laboratories, educational institutions and repeat customers engaged in research work. Feel free to contact us with any queries you have regarding bulk pricing options.
All batches are tested by ISO 17025 accredited third-party laboratory using HPLC and MS/UPLC techniques. Self-certified generic PDF documents are never included in our shipments.