MOTS-c
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) peptide is a mitochondrial product synthesized from the 12S rRNA gene sequence. It has been the subject of research on metabolic homeostasis and insulin sensitivity, as well as AMPK activation.
About MOTS-c
MOTS-c is a peptide made up of 16 amino acids that is exclusively coded by the mitochondrial genome rather than the nuclear genome. Therefore, it forms one of the recent discoveries referred to as MDPs that have immense importance in metabolic studies.
Studies on MOTS-c have been conducted with respect to its significance in AMPK activation, regulation of folate cycle, and metabolic flexibility in skeletal muscles. It has also been examined in relation to insulin sensitivity and aging in metabolic decline.
Research Areas
- AMPK activation and metabolic homeostasis pathway research
- Insulin sensitivity and glucose regulation studies in animal models
- Mitochondrial function and biogenesis investigation in vitro
- Folate and methionine cycle regulation research
- Age-related metabolic decline and longevity research in laboratory settings
- Exercise mimetic and skeletal muscle metabolism studies
⚠ Research Use Only.
All products supplied by PeptidesX are intended strictly for in-vitro laboratory and scientific research. Not for human consumption, medical use, veterinary use, or therapeutic application. Researchers are responsible for compliance with all applicable regulations in their jurisdiction.
Identity & Purity
HPLC / MS-UPLC| Test | Specification | Result |
| Appearance | White lyophilised powder | ✓ Conforms |
| HPLC Purity | ≥ 98.0% | 99.0% ✓ |
| MS Molecular Weight | Expected ± 0.5 Da | Confirmed ✓ |
| Amino Acid Analysis | Theoretical sequence | Confirmed ✓ |
| Water Content (KF) | ≤ 8.0% | 5.4% ✓ |
| Net Peptide Content | ≥ 85.0% | 90.8% ✓ |
Safety Testing
Endotoxin / Metals| Test | Specification | Result |
| Endotoxin (LAL) | ≤ 5 EU/mg | 0.9 EU/mg ✓ |
| Bioburden | ≤ 100 CFU/g | <10 CFU/g ✓ |
| Lead (Pb) | ≤ 10 ppm | <0.1 ppm ✓ |
| Arsenic (As) | ≤ 5 ppm | <0.1 ppm ✓ |
| Mercury (Hg) | ≤ 3 ppm | <0.1 ppm ✓ |
| Cadmium (Cd) | ≤ 5 ppm | <0.1 ppm ✓ |
Solubility: Water / PBS. Mix gently by rolling — do not vortex.
Returns: Sealed, unopened vials may be returned within 14 days of receipt. Opened vials cannot be returned.
MOTS-c is a naturally occurring mitochondrial-derived peptide that plays a role in cellular energy regulation. It has become a major focus of scientific research due to its potential involvement in metabolism, exercise physiology, healthy ageing, and mitochondrial function.
MOTS-c stands for Mitochondrial Open Reading Frame of the 12S rRNA Type-c. It is encoded within mitochondrial DNA, making it unique among many commonly studied research peptides.
Unlike traditional peptides, MOTS-c originates from the mitochondria—the energy-producing structures within cells. Researchers are investigating how it may influence metabolic pathways, energy utilisation, cellular resilience, and age-related biological processes.
Researchers believe MOTS-c functions as a mitochondrial signalling peptide that helps regulate metabolic activity and cellular stress responses. Studies continue to explore its influence on energy production, glucose metabolism, and exercise-related pathways.
Current research areas include:
. Mitochondrial function studies
. Metabolic health research
. Energy regulation investigations
. Exercise physiology research
. Healthy ageing studies
. Glucose metabolism research
. Cellular stress response pathways
. Longevity and lifespan science
Published studies have investigated MOTS-c's role in metabolic adaptation, exercise performance, glucose regulation, and mitochondrial signalling. Ongoing research continues to examine its biological significance and potential applications.
Yes. Metabolic health is one of the primary areas of MOTS-c research. Scientists study how the peptide may influence energy balance, nutrient utilisation, and cellular metabolic pathways.
Exercise physiology is another major area of scientific interest. Researchers continue to investigate how MOTS-c may affect endurance-related pathways, physical performance, and metabolic adaptation to exercise.
MOTS-c is frequently discussed within longevity and healthy ageing research due to its association with mitochondrial function and cellular energy regulation. Scientists continue to explore its potential role in age-related biological processes.
Research-grade MOTS-c is available through specialist peptide suppliers serving the UK research community. Product availability may vary depending on supplier inventory and batch production schedules.
Researchers should buy MOTS-c from reputable suppliers that provide batch-specific Certificates of Analysis, purity testing data, and transparent quality assurance standards.
Yes. Research-grade MOTS-c is available from selected online peptide suppliers. Researchers should review supplier credentials, purity testing, and product documentation before purchasing.
MOTS-c is commonly supplied as a lyophilised peptide powder in various vial strengths. Available concentrations may vary depending on supplier offerings.
High-quality research-grade MOTS-c is typically verified through HPLC and mass spectrometry analysis. Batch-specific purity results are generally available through a Certificate of Analysis.
MOTS-c is commonly supplied as a lyophilised peptide powder and is reconstituted using appropriate laboratory-grade diluents. Researchers should follow established laboratory protocols and handling procedures.
Lyophilised MOTS-c should be stored according to the supplier's recommendations. Appropriate storage conditions help maintain peptide stability and analytical integrity throughout the research process.
Mitochondria are responsible for producing cellular energy and play a critical role in metabolism, ageing, and overall cellular function. Peptides such as MOTS-c are helping researchers better understand mitochondrial communication and regulation.
Researchers should look for:
. Batch-specific Certificates of Analysis
. HPLC purity verification
. Mass spectrometry testing
. Transparent quality control procedures
. Reliable UK shipping
. Consistent product availability
MOTS-c is unique because it originates from mitochondrial DNA rather than nuclear DNA. This distinction has made it one of the most exciting peptides in modern metabolic and longevity research.